![]() Question 11 from the first paper of 2013 and Question 1(p.2) from the first paper of 2008 asked about this in some detail, focusing on creatinine as a biomarker of renal function and specifically on the problems of using it for that purpose, which one question called "limitations" and the other called "pitfalls". This chapter is relevant to the aims of Section H4(ii) from the 2017 CICM Primary Syllabus, which expects the exam candidate to "describe the utility of measurement of serum Creatinine and estimation of Creatinine Clearance". This is commonly represented mathematically asĬ C r = U C r × V P C r Īn online Cockcroft-Gault calculator is at. Since the product of urine concentration and urine flow rate yields creatine's excretion rate, creatinine clearance is also said to be its excretion rate (U Cr×V) divided by its plasma concentration. Clearance is a ratio of the mass generation and concentration at a steady state.Ĭreatinine clearance (C Cr) can be calculated if values for creatinine's urine concentration (U Cr), urine flow rate (V), and creatinine's plasma concentration (P Cr) are known. Physiologically, these quantities (volumetric blood flow and mass removal) are only related loosely. It is commonly believed to be the amount of liquid filtered out of the blood that gets processed by the kidneys. For example grading of chronic renal insufficiency and dosage of drugs that are primarily excreted via urine are based on GFR (creatinine clearance). The result of this test is an important gauge used in assessing excretory function of the kidneys. Since creatinine is already at a steady-state concentration in the blood, measuring creatinine clearance is much less cumbersome. Other more precise GFR measurements involve constant infusions of inulin or another compound, to maintain a steady state in the blood. This margin of error is acceptable considering the ease with which creatinine clearance is measured. It is actively secreted by the kidneys such that creatinine clearance overestimates actual GFR by 10-20%. Glomerular filtration rate (GFR) can be calculated by measuring any chemical that has a steady level in the blood, and is freely filtered but neither reabsorbed nor secreted by the kidneys.Ĭreatinine is used because it fulfills these requirements (though not perfectly) and it is produced naturally by the body ( creatinine is a metabolite of creatine, which is found in muscle). Clinically, creatinine clearance is a useful measure for estimating the glomerular filtration rate (GFR) of the kidneys. In renal physiology, creatinine clearance (C Cr) is the volume of blood plasma that is cleared of creatinine per unit time. In general, creatinine clearance is the removal of creatinine from the body. List of terms related to Creatinine clearanceĮditor-In-Chief: C. Risk calculators and risk factors for Creatinine clearanceĬauses & Risk Factors for Creatinine clearanceĭiagnostic studies for Creatinine clearance Patient resources on Creatinine clearanceĭiscussion groups on Creatinine clearanceĭirections to Hospitals Treating Creatinine clearance US National Guidelines Clearinghouse on Creatinine clearanceīe alerted to news on Creatinine clearance Ongoing Trials on Creatinine clearance at Clinical Ĭlinical Trials on Creatinine clearance at Google ![]() Powerpoint slides on Creatinine clearanceĬochrane Collaboration on Creatinine clearance Most cited articles on Creatinine clearanceĪrticles on Creatinine clearance in N Eng J Med, Lancet, BMJ Most recent articles on Creatinine clearance WikiDoc Resources for Creatinine clearance
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